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January 2018
Using the painkiller Ibuprofen affects testosterone production in men
EDMaRC researcher Anders Juul co-authored a paper publised in PNAS this week describing the results of a randomised clinical trial on the effects of ibuprofen use on male reproductive hormone levels. The clinical trial with young men exposed to ibuprofen showed that the analgesic resulted in the clinical condition named “compensated hypogonadism," a condition prevalent among elderly men and associated with reproductive and physical disorders. The study was a collaboration between Danish and French researchers. 
Read the abstract here 
Mentioning about the study in the press:

 
January 2018
New EDMaRC study shows that D-vitamin treatment may improve sperm production in men with D-vitamin deficiency
 Hear here about the study, which was published in Journal of Clinical Endocrinology and Metabolism in November 2017:

 
January 2018
Article in Human Reproduction on new method for assessing sperm quality
 
Danish EDMaRC scientists, led by senior scientist Kristian Almstrup, have developed a new method for assessing sperm quality. The method may be used to predict what kind of fertility treatment childless couples will benefit most from.
 
Traditionally, semen quality is evaluated in a microscope counting how many sperm cells there are, how well they swim and whether they are malformed or not. However, these parameters are not particularly good at predicting how fertile a man is.
 
New method of assessing the sperm's ability to fertilize an egg
Researchers from EDMaRC and Department of Growth and Reproduction, Copenhagen University Hospital, have therefore been looking for another method to assess how good sperm cells are to fertilize an egg. To penetrate an egg, sperm cells must pass through a rigid barrier (the egg coat or zona pellucida) surrounding the egg. To facilitate this, sperm cells have an acrosome, which releases enzymes that can break down the barrier. The acrosome can be compared to a hat on top of the sperm head that only can be removed when it meets an egg. The researchers have developed a new method that easily can estimate the number of sperm cells with an intact acrosome, and therefore have the potential to fertilize an egg.
 
The number of acrosome-intact sperm cells can predict a man's fertility
Examination of semen samples from more than 230 men showed that over half of the sperm cells had already lost their acrosome, just after the samples were made. In other words, less than half of the sperm cells had the ability to fertilize an egg. Indeed, the number of acrosome-intact sperm cells was found to be good in predicting the fertility of men. Men who became fathers by natural intercourse had significantly more sperm cells with an intact acrosome than men in fertility treatment.
 
Senior researcher Kristian Almstrup, who has been responsible for the study, just published in the journal Human Reproduction, says, "The method allows us to test the fertility of a man in a new way. If a man has few sperm cells with an intact acrosome, then the couple will probably benefit the most from a treatment where a sperm cell is injected directly into the egg. "

Reference:  Egeberg Palme DL, Rehfeld A, Bang AK, Nikolova KA, Kjærulff S, Petersen MR, Jeppesen JV, Glensbjerg M, Juul A, Skakkebæk NE, Ziebe S, Jørgensen N, and Almstrup K. Viable acrosome-intact human spermatozoa in the ejaculate as a marker of semen quality and fertility status. Human Reproduction. DOI: 10.1093 / humrep / dex380

Mentioning of the study in the Danish News (in Danish): 



EDMaRC research has previously shown that some chemicals, including some chemical UV filters, can affect the processes that regulate the human sperm acrosome reaction (Rehfeld et al. EDC IMPACT: Chemical UV filters can affect human sperm function in a progesterone-like manner. Endocr Connect. 2018 Jan;7(1):16-25). The new method can also be used to investigate associations between human exposure and premature acrosome reaction in human sperm.
 
October 2017
Sperm counts, testicular cancers, and the environment
Editorial published in in British Medical Journal by EDMaRC researcher Niels E Skakkebæk (link to BMJ editorial).
 
September 2017
Two EDMaRC Ph.D dissertation defences
In September 2017 two EDMaRC Ph.D students successfully defended their dissertations at the University of Copenhagen. 
September 27th
Anders Rehfeld: Do endocrine disrupting chemicals affect human sperm cell function?
This dissertation on direct effects of environmental chemicals on human sperm cell function in vitro is based on three original publications . A short summary of the dissertations can be read here.
Anders Rehfeld's work has drawn the attention of both national Danish as well as international media including an article on CNN health in 2016.

September 29th
Loa Nordcap: Are stress and adrenal gland activity associated with semen quality and reproductive hormones in men?
A short summary of the dissertation can be read here.
 
July 2017
New study shows a 50-60% decline in sperm counts among men in Western countries over the last 40 years
EDMaRC researcher Niels Jørgensen is one of the co-authors of a new systematic review and meta-regression analysis on temporal trends in sperm count, which recently was published in Human Reproduction Update. The study found a 50-60% decline in sperm counts between 1973 and 2011 among men unselected by fertility from Western Countries (see abstract here). The paper received attention from several media including BBC and CNN
Data from EDMaRC study on male reproductive health were included in the meta analysis.




 
 
 
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